CENTRAL INHIBITORY EFFECT OF INTRAVENOUS KETOPROFEN ON NOCICEPTIVE FLEXION REFLEX IN MAN

被引：0

作者：

WILLER, JC ^{[1
]}

HARREWYN, JM ^{[1
]}

机构：

[1] LABS SPECIAL, UNITE RECH CLIN, F-75646 PARIS 13, FRANCE

来源：

PRESSE MEDICALE | 1987年 / 16卷 / 02期

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In a double-blind, cross-over study, the nociceptive flexion reflex threshold of the biceps femoris was investigated in 10 healthy volunteers before and after intravenous administration of ketoprofen (100 mg in 5 ml) or placebo (5 ml). A significant difference was observed between the increase of reflex threshold produced by ketoprofen (+ 68%) and that produced by the placebo (+ 17%). These results show that ketoprofen has intrinsic inhibitory properties of the nociceptive flexion reflex, which could be explained by a central depressive effect on the transmission of nociceptive messages.

引用

页码：63 / 67

页数：5

共 13 条

[1]

ARCHIMBAUD JP, 1981, ANN UROL, V15, P49

[2] CENTRAL AND PERIPHERAL ANTI-ALGESIC ACTION OF ASPIRIN-LIKE DRUGS [J].

FERREIRA, SH ;

LORENZETTI, BB ;

CORREA, FMA .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 53 (01) :39-48

[3]

GUYONNET JC, 1976, RHEUMATOL REHABIL, P11

[4]

JULOU L, 1976, RHEUMATOL REHABIL, P5

[5]

LIM RKS, 1968, PHARMACOLOGY PAIN, P169

[6]

MARTIO J, 1981, BRIT J CLIN PRACT, V35, P265

[7] DIFFUSION OF INTRAMUSCULAR KETOPROFEN INTO THE CEREBROSPINAL-FLUID [J].

NETTER, P ;

LAPICQUE, F ;

BANNWARTH, B ;

TAMISIER, JN ;

THOMAS, P ;

ROYER, RJ .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1985, 29 (03) :319-321

[8]

POURRAT JP, 1984, PRESSE MED, V13, P2125

[9] CENTRAL EFFECTS OF ZOMEPIRAC ON PAIN EVOKED BY INTRANEURAL STIMULATION IN MAN [J].

SCHADY, W ;

TOREBJORK, HE .

JOURNAL OF CLINICAL PHARMACOLOGY, 1984, 24 (10) :429-435

[10] STUDIES ON PAIN - EFFECTS OF MORPHINE ON A SPINAL NOCICEPTIVE FLEXION REFLEX AND RELATED PAIN SENSATION IN MAN [J].

WILLER, JC .

BRAIN RESEARCH, 1985, 331 (01) :105-114

← 1 2 →