ANTICONVULSANT ACTIVITY OF AMPA KAINATE ANTAGONISTS - COMPARISON OF GYKI 52466 AND NBQX IN MAXIMAL ELECTROSHOCK AND CHEMOCONVULSANT SEIZURE MODELS

被引：128

作者：

YAMAGUCHI, S ^{[1
]}

DONEVAN, SD ^{[1
]}

ROGAWSKI, MA ^{[1
]}

机构：

[1] NINCDS, NEURONAL EXCITABIL SECT,EPILEPSY RES BRANCH, BLDG 10,ROOM 5C-205, BETHESDA, MD 20892 USA

来源：

EPILEPSY RESEARCH | 1993年 / 15卷 / 03期

关键词：

ANTICONVULSANT DRUGS; COMPETITIVE AND NONCOMPETITIVE NON-NMDA ANTAGONISTS; EXPERIMENTAL SEIZURES;

D O I：

10.1016/0920-1211(93)90054-B

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The anticonvulsant activities of a noncompetitive (GYKI 52466) and a competitive (NBQX) AMPA/kainate antagonist were compared in the maximal electroshock (MES) seizure test and various chemoconvulsant models. Both antagonists were protective in the MES and pentylenetetrazol tests. GYKI 52466 was also protective against seizures and lethality induced by 4-aminopyridine, kainate and AMPA, but not by NMDA, whereas NBQX was ineffective in these chemoconvulsant tests. Both GYKI 52466 and NBQX produced motor impairment at doses similar to those that were protective in the MES test. Under some circumstances, noncompetitive AMPA/kainate antagonists could offer advantages over competitive antagonists in seizure therapy. However, neurological toxicity is an obstacle to the potential clinical use of both classes of agents.

引用

页码：179 / 184

页数：6

共 22 条

[1] THE ANTICONVULSANT EFFECT OF THE NON-NMDA ANTAGONISTS, NBQX AND GYKI-52466, IN MICE [J].