SCAVENGING ACTIVITY OF AZELAIC ACID ON HYDROXYL RADICALS INVITRO

被引：32

作者：

PASSI, S ^{[1
]}

PICARDO, M ^{[1
]}

DELUCA, C ^{[1
]}

BREATHNACH, AS ^{[1
]}

NAZZAROPORRO, M ^{[1
]}

机构：

[1] ST THOMAS HOSP,SCH MED,LONDON SE1 7EH,ENGLAND

来源：

FREE RADICAL RESEARCH COMMUNICATIONS | 1991年 / 11卷 / 06期

关键词：

AZELAIC ACID; FENTON AND PHOTO-FENTON TYPE REACTIONS; HYDROXYLRADICALS; MANNITOL;

D O I：

10.3109/10715769109088931

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Azelaic acid is an aliphatic dicarboxylic acid (HOOC-(CH2)7-COOH) which has recently been shown to have some practical therapeutic applications in skin diseases of different etiologies. It possesses diverse biological activities and its mechanisms of action are still under investigation. Azelaic acid, as disodium salt (C92Na), at concentrations from 0.05 mM to 1.0 mM is capable of inhibiting significantly the hydroxylation of l-tyrosine to l-DOPA due to hydroxylradicals (HO) produced by Fenton reaction. Similarly C9,2Na significantly inhibits the heterogeneous photocatalytic oxidation of toluene to cresols, and the peroxidation of arachidonic acid (C20: 4, n6), due to HO formed by dissolved oxygen in the presence of UV-irradiated semiconductor TiO2 (photo-Fenton type reaction). C92Na decomposition and its by-products formation are quantifiable only at high HO concentrations. On the contrary, C92Na is not a scavenger of O2 generated by xanthine-xanthine oxidase system. Under the same experimental conditions, mannitol behaves like C92Na. These data indicate that HO scavenging capacity of C92Na in vitro and represent a useful tool for further investigations on the mechanisms of action of azelaic acid in biological systems. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：329 / 338

页数：10

共 22 条

[1]

Breathnach A S, 1989, Acta Derm Venereol Suppl (Stockh), V143, P62

[2] AZELAIC ACID THERAPY IN DISORDERS OF PIGMENTATION [J].