NCAM (CD56)-POSITIVE MALIGNANT-LYMPHOMA

被引：39

作者：

KERN, WF

SPIER, CM

MILLER, TP

GROGAN, TM

机构：

[1] Department of Pathology, University of Arizona and the Arizona Cancer Center, Tucson, AZ

[2] Southwest Oncology Group, San Antonio, TX

[3] Department of the Southwest Oncology Group Central Lymphoma Repository, University of Arizona and the Arizona Cancer Center, San Antonio, TX

来源：

LEUKEMIA & LYMPHOMA | 1993年 / 12卷 / 1-2期

关键词：

MALIGNANT LYMPHOMA; LOCALIZATION; CELL ADHESION MOLECULES; NEURAL CELL ADHESION MOLECULE; CD56; POLYSIALIC ACID;

D O I：

10.3109/10428199309059565

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CD56 has been found to identify an isoform of the neural cell adhesion (NCAM). NCAM is a member of the immunoglobulin superfamily of cell adhesion molecules; it is related to a variety of leukocyte antigens and to several cell adhesion molecules believed relevant to malignant behavior in a variety of neoplasms. It contains polysialic acid, which appears to regulate binding avidity of NCAM and other cell adhesion processes. We have identified a group of NCAM-positive lymphomas. Compared to a group of NCAM-negative lymphomas, this group exhibited frequent involvement of unusual sites and a generally aggressive course. Another series of CD56-positive hematolymphoid malignancies has recently been described, from Hong Kong; this group also exhibited involvement of unusual sites and displayed a very aggressive course. Together these series suggest that NCAM on lymphoma is of biological and clinical significance in terms of tumor behavior and spread.

引用

页码：1 / &

共 61 条

[1]

Kern W.F., Spier C.M., Hanneman E.H., Miller T.P., Matzner M., Grogan T.M., Neural cell adhesion molecule-positive peripheral T-cell lymphoma: A rare variant with a propensity for unusual sites of involvement, Blood, 79, pp. 2432-2437, (1992)

[2]

Wong K.F., Chan J.K.C., Ng C.S., Lee K.C., Tsang W.Y.W., Cheung M.M.C., CD56(NKH-1)-positive hematolymphoid malignancies: An aggressive neoplasm featuring frequent cutaneous/mucosal involvement, cytoplasmic azurophilic granules, and angiocentricity, Hum. Pathol., 23, pp. 798-804, (1992)

[3]

Edelman G.M., Cell adhesion molecules in the regulation of animal form and tissue pattern, Ann. Rev. Cell Bio., 2, pp. 81-116, (1986)

[4]

Zetter B.R., The cellular basis of site-specific tumor metastasis, N. Eng. J. Med., 322, pp. 605-612, (1990)

[5]

Liotta L.A., Stetler-Stevenson W.G., Principles of molecular cell biology of cancer: Cancer metastasis, Cancer: Principles & Practice of Oncology, pp. 98-115, (1989)

[6]

Edelman G.M., Morphoregulatory molecules, Biochemistry, 27, pp. 3533-3543, (1988)

[7]

Rutishauser U., Jessell T.M., Cell adhesion molecules in vertebrate development, Physiol. Rev., 68, pp. 819-857, (1990)

[8]

Williams A.F., Barclay A.N., The immunoglobulin superfamily-Domains for cell surface recognition, Ann. Rev. Immunol., 6, pp. 381-405, (1988)

[9]

Fearon E.R., Cho K.R., Nigro J.M., Kern S.E., Simons J.W., Ruppert J.M., Hamilton S.R., Preisinger A.C., Thomas G., Kinzler K.W., Vogelstein B., Identification of a chromosome 18q gene that is altered in colorectal cancer, Science, 247, pp. 49-56, (1990)

[10]

Edelman G.M., CAMs and Igs: Cell adhesion and the evolutionary origins of immunity, Immunol. Rev., 100, pp. 10-45, (1987)

← 1 2 3 4 5 6 7 →