A T-CELL DORMANT STATE IN THE AUTOIMMUNE PROCESS OF NONOBESE DIABETIC MICE TREATED WITH COMPLETE FREUND ADJUVANT

被引：52

作者：

ULAETO, D ^{[1
]}

LACY, PE ^{[1
]}

KIPNIS, DM ^{[1
]}

KANAGAWA, O ^{[1
]}

UNANUE, ER ^{[1
]}

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT MED,ST LOUIS,MO 63110

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 09期

关键词：

INSULIN-DEPENDENT DIABETES-MELLITUS; AUTOIMMUNITY; ADJUVANTS;

D O I：

10.1073/pnas.89.9.3927

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Three experimental manipulations showed the suppressive effect of injection of complete Freund's adjuvant (CFA) in the diabetic state of nonobese diabetic (NOD) mice. (i) Diabetes was inhibited in young NOD mice injected with the adjuvant. (ii) Recurrence of diabetes in mice transplanted with pancreatic islets was also inhibited when the recipients were injected with CFA. (iii) Injection of spleen lymphocytes from diabetic mice into male NOD mice transferred the diabetic state, but this transfer was markedly suppressed when the recipients were treated with CFA. In all three cases the spleen cells from the normoglycemic mice treated with CFA induced diabetes when transferred into NOD male mice. CFA, therefore, induces a state of T-cell dormancy, in which the islets are no longer subject to an immune attack.

引用

页码：3927 / 3931

页数：5

共 20 条

[1]

ASHERSON GL, 1971, CLIN EXP IMMUNOL, V9, P249

[2] SYNGENEIC TRANSFER OF AUTOIMMUNE DIABETES FROM DIABETIC NOD MICE TO HEALTHY NEONATES - REQUIREMENT FOR BOTH L3T4+ AND LYT-2+ T-CELLS [J].