SHORT-TERM TISSUE-CULTURE OF HUMAN-BREAST CANCER - PRESENCE OF ESTROGEN RECEPTORS AND 17-BETA-ESTRADIOL STIMULATION OF RNA-SYNTHESIS

被引：0
作者：
SANFILIPPO, O
DAIDONE, MG
DIFRONZO, G
SILVESTRINI, R
机构：
[1] IST NAZL TUMORI, CINET CELLULARE LAB, I-20133 MILAN, ITALY
[2] IST NAZL TUMORI, FARMACOCINET CLIN, I-20133 MILAN, ITALY
来源：
CANCER | 1979年 / 43卷 / 06期
关键词：
D O I：
10.1002/1097-0142(197906)43:6<2365::AID-CNCR2820430629>3.0.CO;2-U
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The stimulation of RNA synthesis induced by estradiol has been studied on 60 breast cancers in short‐term cultures. In the same tumors the estrogen receptor (ER) assay was carried out. In 35% of the cases studied the stimulating effect by estradiol in vitro was observed. The frequency of response to in vitro hormone treatment was higher (42%) in ER+ cancers and lower (25%) in ER−cancers. The specificity of the in vitro test was assessed by the use of tamoxifen. Copyright © 1979 American Cancer Society
引用
收藏
页码：2365 / 2369
页数：5
相关论文
共 22 条
[1]  
ASPEGREN K, 1974, ACTA CHIR SCAND, V140, P95
[2]   INVITRO ASSAY FOR HUMAN BREAST-CANCER HORMONE RESPONSIVENESS - STUDY OF 25 CASES WITH CLINICAL CORRELATION [J].
BURSTEIN, NA ;
CAREY, RW .
ONCOLOGY, 1974, 29 (06) :470-483
[3]  
CHAN PC, 1976, P SOC EXP BIOL MED, V151, P362, DOI 10.3181/00379727-151-39210
[4]   EFFECT OF TESTOSTERONE AND ESTRADIOL-17BETA ON SYNTHESIS OF DNA, RNA AND PROTEIN IN HUMAN BREAST IN ORGAN-CULTURE [J].
FINKELSTEIN, M ;
GEIER, A ;
HORN, H ;
LEVIJ, IS ;
EVERHADANI, P .
INTERNATIONAL JOURNAL OF CANCER, 1975, 15 (01) :78-90
[5]  
GAROLA RE, 1977, CANCER RES, V37, P3333
[6]   EARLY EFFECTS OF ESTRADIOL-17BETA ON CHROMATIN AND ACTIVITY OF DEOXYRIBONUCLEIC ACID-DEPENDENT RIBONUCLEIC-ACID POLYMERASES (I AND II ) OF RAT UTERUS [J].
GLASSER, SR ;
CHYTIL, F ;
SPELSBERG, TC .
BIOCHEMICAL JOURNAL, 1972, 130 (04) :947-957
[7]  
HAMILTON TH, 1968, J BIOL CHEM, V243, P408
[8]   SEQUENTIAL STIMULATIONS BY OESTROGEN OF NUCLEAR RNA SYNTHESIS AND DNA-DEPENDENT RNA POLYMERASE ACTIVITIES IN RAT UTERUS [J].
HAMILTON, TH ;
WIDNELL, CC ;
TATA, JR .
BIOCHIMICA ET BIOPHYSICA ACTA, 1965, 108 (01) :168-&
[9]   PREDICTING RESPONSE TO ENDOCRINE THERAPY IN HUMAN BREAST-CANCER - HYPOTHESIS [J].
HORWITZ, KB ;
MCGUIRE, WL ;
PEARSON, OH ;
SEGALOFF, A .
SCIENCE, 1975, 189 (4204) :726-727
[10]   MONOHYDROXYLATED METABOLITE OF TAMOXIFEN WITH POTENT ANTI-ESTROGENIC ACTIVITY [J].
JORDAN, VC ;
COLLINS, MM ;
ROWSBY, L ;
PRESTWICH, G .
JOURNAL OF ENDOCRINOLOGY, 1977, 75 (02) :305-316
123