WHY ARE PROTEINS O-GLYCOSYLATED

被引：675
作者：
JENTOFT, N [1 ]
机构：
[1] CASE WESTERN RESERVE UNIV,DEPT BIOCHEM,CLEVELAND,OH 44106
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1990年 / 15卷 / 08期
关键词：
D O I：
10.1016/0968-0004(90)90014-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The O-linked oligosaccharides of glycoproteins are usually clustered within heavily glycosylated regions of the peptide chain. Steric interactions between carbohydrate and peptide within these clusters induce the peptide core to adopt a stiff and extended conformation and this conformational effect appears to represent a major function of O-glycosylation. © 1990.
引用
收藏
页码：291 / 294
页数：4
相关论文
共 32 条
  • [1] CELL-SURFACE CARBOHYDRATES IN CELL RECOGNITION AND RESPONSE
    BRANDLEY, BK
    SCHNAAR, RL
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 1986, 40 (01) : 97 - 111
  • [2] CARLSTEDT I, 1985, ESSAYS BIOCHEM, V20, P40
  • [3] FURTHER-STUDIES ON RELATIONSHIP BETWEEN LARGE GLYCOPROTEIN MOLECULES AND ALLOTRANSPLANTABILITY IN TA3 TUMOR OF MOUSE - STUDIES ON SEGREGATING TA3-HA HYBRIDS
    CODINGTON, JF
    KLEIN, G
    COOPER, AG
    LEE, N
    BROWN, MC
    JEANLOZ, RW
    [J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1978, 60 (04) : 811 - 818
  • [4] TOPOLOGY AND QUATERNARY STRUCTURE OF PRO-SUCRASE ISOMALTASE AND FINAL-FORM SUCRASE ISOMALTASE
    COWELL, GM
    TRANUMJENSEN, J
    SJOSTROM, H
    NOREN, O
    [J]. BIOCHEMICAL JOURNAL, 1986, 237 (02) : 455 - 461
  • [5] DAVIS CG, 1986, J BIOL CHEM, V261, P2828
  • [6] EFFECTS OF GLYCOSYLATION ON THE CONFORMATION AND DYNAMICS OF O-LINKED GLYCOPROTEINS - C-13 NMR-STUDIES OF OVINE SUBMAXILLARY MUCIN
    GERKEN, TA
    BUTENHOF, KJ
    SHOGREN, R
    [J]. BIOCHEMISTRY, 1989, 28 (13) : 5536 - 5543
  • [7] A CORE PROTEIN EPITOPE OF THE POLYMORPHIC EPITHELIAL MUCIN DETECTED BY THE MONOCLONAL-ANTIBODY SM-3 IS SELECTIVELY EXPOSED IN A RANGE OF PRIMARY CARCINOMAS
    GIRLING, A
    BARTKOVA, J
    BURCHELL, J
    GENDLER, S
    GILLETT, C
    TAYLORPAPADIMITRIOU, J
    [J]. INTERNATIONAL JOURNAL OF CANCER, 1989, 43 (06) : 1072 - 1076
  • [8] ALTERED EXPRESSION OF LEUKOCYTE SIALOGLYCOPROTEIN IN WISKOTT-ALDRICH SYNDROME IS ASSOCIATED WITH A SPECIFIC DEFECT IN O-GLYCOSYLATION
    GREER, WL
    HIGGINS, E
    SUTHERLAND, DR
    NOVOGRODSKY, A
    BROCKHAUSEN, I
    PEACOCKE, M
    RUBIN, LA
    BAKER, M
    DENNIS, JW
    SIMINOVITCH, KA
    [J]. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 1989, 67 (09): : 503 - 509
  • [9] HART GW, 1989, ANNU REV BIOCHEM, V58, P841
  • [10] THE SUCRASE-ISOMALTASE COMPLEX - PRIMARY STRUCTURE, MEMBRANE-ORIENTATION, AND EVOLUTION OF A STALKED, INTRINSIC BRUSH-BORDER PROTEIN
    HUNZIKER, W
    SPIESS, M
    SEMENZA, G
    LODISH, HF
    [J]. CELL, 1986, 46 (02) : 227 - 234
1234