COCAINE AND SEVERAL SIGMA-RECEPTOR LIGANDS INHIBIT DOPAMINE UPTAKE IN RAT CAUDATE-PUTAMEN

被引：46
作者：
IZENWASSER, S
NEWMAN, AH
KATZ, JL
机构：
[1] Psychobiology Section, NIDA Addiction Research Center, Baltimore, MD 21224
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 243卷 / 02期
关键词：
DOPAMINE UPTAKE; COCAINE; CAUDATE-PUTAMEN; SIGMA-RECEPTORS; RIMCAZOLE; 3H]CFT ([3H]2-BETA-CARBOMETHOXY-3-BETA-(4-FLUORO-PHENYL)-TROPANE, [3H]WIN 35,428);
D O I：
10.1016/0014-2999(93)90381-Q
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cocaine and several sigma receptor ligands inhibit dopamine uptake via a common site. This is evidenced by a concentration-dependent inhibition of dopamine uptake and displacement of the binding of [H-3]WIN 35,428 (also called CFT), a cocaine analog with high affinity for the dopamine transporter. Since several sigma receptor ligands have been shown to block the stimulant effects of cocaine, this site may serve as a target for future drug development to treat cocaine abuse.
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收藏
页码：201 / 205
页数：5
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