A NEW ENANTIOSELECTIVE SYNTHESIS OF TRANS 2,5-DISUBSTITUTED PYRROLIDINE DERIVATIVES BY RADICAL CYCLIZATION

被引：14

作者：

YUASA, Y ^{[1
]}

ANDO, J ^{[1
]}

SHIBUYA, S ^{[1
]}

机构：

[1] TOKYO COLL PHARM,HACHIOJI,TOKYO 19203,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 04期

关键词：

D O I：

10.1039/c39940000455

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new and highly enantioselective synthesis of trans 5-substituted 2-hydroxymethylpyrrolidine derivatives is achieved by intramolecular radical cyclization at the 4-position of Delta(4,5)-oxazolidin-2-one, which leads to c(2)-symmetrical 2,5-dibenzyloxypyrrolidin-2-one.

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页码：455 / 456

页数：2

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