NEUROPROTECTIVE EFFECTS OF ALPHA-DIHYDROERGOCRYPTINE AGAINST DAMAGES IN THE SUBSTANTIA-NIGRA CAUSED BY SEVERE TREATMENT WITH 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE

被引：22

作者：

BERNOCCHI, G

GERZELI, G

SCHERINI, E

VIGNOLA, C

机构：

[1] Dipartimento di Biologia Animale, Universita' di Pavia, Centro di Studio per l'Istochimica del C.N.R., Pavia, I-27100

来源：

ACTA NEUROPATHOLOGICA | 1993年 / 85卷 / 04期

关键词：

ALPHA-DIHYDROERGOCRYPTINE; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; SUBSTANTIA-NIGRA;

D O I：

10.1007/BF00334452

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effects on the substantia nigra of alpha-dihydroergocryptine (DEK), a drug with strong dopaminomimetic activity, were tested with a severe 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment in monkeys. Compared with monkeys treated with MPTP alone. the animals which received DEK plus MPTP showed reduced neuronal death in the substantia nigra.The reactive astrocytes were increased in number. Moreover, several axons which were immunopositive to phosphorylated neurofilament proteins and with features similar to those of control animals were seen in the pars compacta.The findings suggest that DEK preserves neuronal morphology and brain architecture.

引用

页码：404 / 413

页数：10

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