EFFECTS OF LINDANE ON THE ACCUMULATION OF CYCLIC-AMP, INDUCED BY VASOACTIVE-INTESTINAL-PEPTIDE, IN ISOLATED RAT PROSTATIC EPITHELIAL-CELLS

被引：9

作者：

CARRERO, I ^{[1
]}

PEREZALBARSANZ, MA ^{[1
]}

RECIO, MN ^{[1
]}

PRIETO, JC ^{[1
]}

机构：

[1] UNIV ALCALA DE HENARES, DEPT BIOQUIM & BIOL MOLEC, E-28871 ALCALA DE HENARES, SPAIN

来源：

TOXICOLOGY IN VITRO | 1992年 / 6卷 / 01期

关键词：

D O I：

10.1016/0887-2333(92)90079-7

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Lindane pretreatment of isolated rat prostatic epithelial cells resulted in a time- and dose-dependent impairment of the stimulation of cyclic AMP levels by vasoactive intestinal peptide (VIP); the optimal conditions for producing this impairment were found to be 5 min of cell exposure to 0.2 mM-lindane at 25-degrees-C. The inhibitory effect of the insecticide was related to a decrease in VIP efficiency since the maximal cyclic AMP response (at 100 nM VIP) was about 50% of that in control cells. VIP potency was unaffected since the half-maximal cyclic AMP response was elicited at about 3 nM VIP in both the control and lindane-pretreated cells. The results indicate that lindane interferes with the cyclic AMP system in prostatic epithelium, and this could be a consequence of some interaction in the prostate gland between the two main systems for signal transduction (i.e. adenylate cyclase and phosphatidylinositol/Ca2+/protein kinase C).

引用

页码：7 / 9

页数：3

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