MECHANISMS OF POLYMER DEGRADATION IN IMPLANTABLE DEVICES .1. POLY(CAPROLACTONE)

被引：131

作者：

ALI, SAM ^{[1
]}

ZHONG, SP ^{[1
]}

DOHERTY, PJ ^{[1
]}

WILLIAMS, DF ^{[1
]}

机构：

[1] ROYAL LIVERPOOL UNIV HOSP, DEPT CLIN ENGN, POB 147, LIVERPOOL L69 3BX, ENGLAND

来源：

BIOMATERIALS | 1993年 / 14卷 / 09期

关键词：

POLY(CAPROLACTONE); FREE RADICALS; CHEMICAL HYDROLYSIS; IN-VIVO DEGRADATION;

D O I：

10.1016/0142-9612(93)90063-8

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Poly(caprolactone) is a biodegradable aliphatic (poly(a-hydroxy acid), with important applications in the field of human therapy, due to its biocompatibility and bioresorbability. The degradation of poly(a-hydroxy acids) depends on chemical hydrolysis, but there is much interest in the precise mechanisms, including the role of free radicals, especially oxygen free radicals and their role in human disease. The hydrolytic degradation of poly(caprolactone) in aqueous environments was used as the control in a study of the effects of hydroxyl radicals in aqueous solutions. Different methods (GPC, DSC, SEM) were employed to investigate the mechanism of degradation of this semicrystalline physiologically absorbable polymer. The data indicate that hydroxyl radical is likely to be a major factor in the degradation of this polymer.

引用

页码：648 / 656

页数：9

共 37 条

[11]

GILDING DK, 1981, FUNDAMENTAL ASPECTS, V1, P43

[12]

Haber F., 1934, P ROY SOC A-MATH PHY, V147, P332, DOI DOI 10.1098/rspa.1934.0221

[13] OXYGEN-TOXICITY, OXYGEN RADICALS, TRANSITION-METALS AND DISEASE [J].

HALLIWELL, B ;

GUTTERIDGE, JMC .

BIOCHEMICAL JOURNAL, 1984, 219 (01) :1-14

[14] OXYGEN FREE-RADICALS AND IRON IN RELATION TO BIOLOGY AND MEDICINE - SOME PROBLEMS AND CONCEPTS [J].

HALLIWELL, B ;

GUTTERIDGE, JMC .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1986, 246 (02) :501-514

[15] POLYMERS FOR BIODEGRADABLE MEDICAL DEVICES .2. HYDROXYBUTYRATE-HYDROXYVALERATE COPOLYMERS - HYDROLYTIC DEGRADATION STUDIES [J].

HOLLAND, SJ ;

JOLLY, AM ;

YASIN, M ;

TIGHE, BJ .

BIOMATERIALS, 1987, 8 (04) :289-295

[16]

KOSSOVSKY N, 1987, CRIT REV BIOCOMPAT, V3, P53

[17] STRUCTURE PROPERTY RELATIONSHIPS IN THE CASE OF THE DEGRADATION OF MASSIVE POLY(ALPHA-HYDROXY ACIDS) IN AQUEOUS-MEDIA .2. DEGRADATION OF LACTIDE-GLYCOLIDE COPOLYMERS - PLA37.5GA25 AND PLA75GA25 [J].

LI, SM ;

GARREAU, H ;

VERT, M .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1990, 1 (03) :131-139

[18] STRUCTURE-PROPERTY RELATIONSHIPS IN THE CASE OF THE DEGRADATION OF MASSIVE POLY(ALPHA-HYDROXY ACIDS) IN AQUEOUS-MEDIA .3. INFLUENCE OF THE MORPHOLOGY OF POLY(L-LACTIC ACID) [J].

LI, SM ;

GARREAU, H ;

VERT, M .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1990, 1 (04) :198-206

[19] STRUCTURE PROPERTY RELATIONSHIPS IN THE CASE OF THE DEGRADATION OF MASSIVE ALIPHATIC POLY-(ALPHA-HYDROXY ACIDS) IN AQUEOUS-MEDIA .1. POLY(DL-LACTIC ACID) [J].

LI, SM ;

GARREAU, H ;

VERT, M .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1990, 1 (03) :123-130

[20] SUBCUTANEOUS IMPLANTS OF POLYPROPYLENE FILAMENTS [J].

LIEBERT, TC ;

CHARTOFF, RP ;

COSGROVE, SL ;

MCCUSKEY, RS .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1976, 10 (06) :939-951

← 1 2 3 4 →