NOVEL EPITOPES ON THE CA50-CARRYING ANTIGEN - CHEMICAL AND IMMUNOCHEMICAL STUDIES

被引：50

作者：

JOHANSSON, C ^{[1
]}

NILSSON, O ^{[1
]}

BAECKSTROM, D ^{[1
]}

JANSSON, EL ^{[1
]}

LINDHOLM, L ^{[1
]}

机构：

[1] GOTHENBURG UNIV,DEPT MED MICROBIOL & IMMUNOL,S-41124 GOTHENBURG,SWEDEN

来源：

TUMOR BIOLOGY | 1991年 / 12卷 / 03期

关键词：

C50; ANTIBODY; CANCER ANTIGEN; TUMOR-ASSOCIATED ANTIGEN; TUMOR MARKER; MONOCLONAL ANTIBODIES;

D O I：

10.1159/000217701

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Novel tumour-associated epitopes showing elevated levels in sera from patients with colon carcinoma were studied by means of monoclonal antibodies with respect to co-expression with the tumour-associated epitope CA50 on the cancer antigen (CanAg) glycoconjugate complex. Co-expression of the different epitopes and CA50 was found on CanAg both from COLO 205 spent medium and sera from patients with colorectal cancer. In a few sera from patients with non-mucinous ovarian tumours, the CanAg complex was also found to express the CA125 epitope. The chemical characterisation showed that all of the novel epitopes on CanAg were of carbohydrate nature, and the results may suggest a structural relationship between several of them.

引用

页码：159 / 170

页数：12

共 36 条

[1] REACTIVITY OF A MONOCLONAL-ANTIBODY WITH HUMAN OVARIAN-CARCINOMA [J].

BAST, RC ;

FEENEY, M ;

LAZARUS, H ;

NADLER, LM ;

COLVIN, RB ;

KNAPP, RC .

JOURNAL OF CLINICAL INVESTIGATION, 1981, 68 (05) :1331-1337

[2] MONITORING HUMAN OVARIAN-CARCINOMA WITH A COMBINATION OF CA-125, CA-19-9, AND CARCINOEMBRYONIC ANTIGEN [J].

BAST, RC ;

KLUG, TL ;

SCHAETZL, E ;

LAVIN, P ;

NILOFF, JM ;

GREBER, TF ;

ZURAWSKI, VR ;

KNAPP, RC .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1984, 149 (05) :553-559

[3]

BASU A, 1987, CANCER RES, V47, P2531

[4]

BLIND PJ, 1987, ACTA CHIR SCAND, V153, P45

[5]

BROCKHAUS M, 1981, J BIOL CHEM, V256, P3223

[6]

DAVIS HM, 1986, CANCER RES, V46, P6143

[7] SEPARATION OF GANGLIOSIDES ON A NEW TYPE OF ANION-EXCHANGE RESIN [J].

FREDMAN, P ;

NILSSON, O ;

TAYOT, JL ;

SVENNERHOLM, L .

BIOCHIMICA ET BIOPHYSICA ACTA, 1980, 618 (01) :42-52

[8]

FUKUSHI Y, 1984, J BIOL CHEM, V259, P511

[9] A NOVEL DISIALOGANGLIOSIDE (IV3NEUACIII6NEUACLC4) OF HUMAN ADENOCARCINOMA AND THE MONOCLONAL-ANTIBODY (FH9) DEFINING THIS DISIALOSYL STRUCTURE [J].

FUKUSHI, Y ;

NUDELMAN, E ;

LEVERY, SB ;

HIGUCHI, T ;

HAKOMORI, S .

BIOCHEMISTRY, 1986, 25 (10) :2859-2866

[10]

FUKUSHIMA K, 1984, CANCER RES, V44, P5279

← 1 2 3 4 →