DRUG-DRUG INTERACTIONS IN PATIENTS DISTRESS FROM HYPERTENSION IN TERTIARY CARE HOSPITAL

Drug-Drug Interactions (DDIs) is an important issue and now it is also realized that many of them can be explained by change in the enzymes, which involve in metabolism that are present in and out of liver. Co-administration of some drugs act as enzyme inducers, whereas some are inhibitors of enzyme which results undesirable effects. Hypertension (HTN) is a most common cardiovascular disease which can be defined as "consistently elevated blood pressure (arterial) or average systolic blood pressure >= 140 mm Hg, or diastolic blood pressure >= 90 mm Hg". It is a disease which has a high global burden which is a worldwide public health challenge as well as a leading risk factor of mortality. The study was a prospective observational study and conducted at a tertiary care hospital at Suraram, Telangana, India. The study were carried over two months. Designing a Proforma for data collection. Analyzing the prescription and categorizing it into varieties based on antibiotics prescribed, route of administration and combinations. 100 HTN patient's prescription's were collected from different departments of Malla Reddy Hospital. Of which 45 prescription's showed DDIs and 55 prescription don't have DDIs. Out of 45 DDI's prescriptions 15 were male patients and 30 female patients. Prescription then evaluated using Standard Drug Interaction Software i.e. Lexi-comp's Lexi-Interact to check the Degree of DDIs.