ENZYME MIMICS

被引：25

作者：

BRESLOW, R

机构：

[1] Department of Chemistry, Columbia University, New York, New York

来源：

PURE AND APPLIED CHEMISTRY | 1990年 / 62卷 / 10期

关键词：

D O I：

10.1351/pac199062101859

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Binding both ends of a substrate to a catalyst can lead to selective functionalization reactions, and also to very strong binding. Attachment of coenzymes such as pyridoxamine or thiamine derivatives to binding groups produces catalysts that show enzyme-like selectivities. When two functional groups are attached to a binding group the resulting catalysts are good mimics of enzymatic transaminases and ribonucleases. Studies on enzyme mimics show the importance of limiting the degrees of freedom in a catalyst, but retaining some flexibility. © 1990, IUPAC.

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页码：1859 / 1866

页数：8

相关论文

共 31 条

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (06) :1746-1750

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