CYTOCHALASIN-D SUPPRESSES SOUND EVOKED-POTENTIALS IN THE GUINEA-PIG COCHLEA

被引：9
作者：
BARRON, SE
BOBBIN, RP
GUTH, P
NORRIS, C
机构：
[1] LOUISIANA STATE UNIV, MED CTR,KRESGE HEARING RES S, DEPT OTORHINOLARYNGOL & BIOCOMMUN,SUITE A, NEW ORLEANS, LA 70112 USA
[2] TULANE UNIV, SCH MED, DEPT PHARMACOL, NEW ORLEANS, LA 70112 USA
来源：
HEARING RESEARCH | 1987年 / 31卷 / 02期
关键词：
D O I：
10.1016/0378-5955(87)90120-1
中图分类号：
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号：
100104 ; 100213 ;
摘要：
Cytochalasin D (CD), an inhibitor of actin polymerization, was perfused through the guinea pig cochlea while monitoring various cochlear potentials. CD (10-7-10-5 M) reduced the magnitude of the compound action potential of the cochlear nerve and the summating potential, and increased N1 latency. The cochlear microphonic potential was the least sensitive potential with only a slight effect being observed at 10-5 M. The results are consistent with the hypothesis that actin has a role in cochlear function.
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页码：147 / 153
页数：7
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