DIVERSITY AND SPECIFICITY IN TRANSCRIPTIONAL REGULATION - THE BENEFITS OF HETEROTYPIC DIMERIZATION

被引：316
作者：
LAMB, P
MCKNIGHT, SL
机构：
[1] Howard Hughes Research Laboratory, Carnegie Institution of Washington, Baltimore, MD 21210
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1991年 / 16卷 / 11期
关键词：
D O I：
10.1016/0968-0004(91)90167-T
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Many eukaryotic transcription factors contain domains that mediate the formation of homo- and heterodimers. The widespread occurrence of such domains suggests that they are important to the genetic regulatory apparatus. In this review we explore the contributions that heterotypic dimerization may make to the generation of regulatory diversity.
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页码：417 / 422
页数：6
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