NOVEL EPIMERIZATION OF STEROIDAL ALLYLIC ALCOHOLS

被引：0

作者：

MORI, M

IKEGAMI, S

TAMAOKI, BI

机构：

[1] NATL INST RADIOL SCI, CHIBA 260, JAPAN

[2] TEIKYO UNIV, FAC PHARMACEUT SCI, SAGAMIKO, KANAGAWA 19901, JAPAN

来源：

STEROIDS | 1979年 / 33卷 / 04期

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epimerization of 4-pregnene-3.beta.,20.alpha.-diol into 4-pregnene-3.alpha.,20.alpha.-diol was achieved under the mild condition of an acidic medium at room temperature. This reaction was favorable for synthesis of 4-pregnene-3.alpha.,20.alpha.-diol in better yield, after chemical reduction of 20.alpha.-hydroxy-4-pregnen-3-one with metal hydrides, which resulted in predominant production of 4-pregnene-3.beta.,20.alpha.-diol. The by product which was formed by raising the temperature was identified as 3,5-pregnadien-20.alpha.-ol. This method was also applicable for epimerization of other .DELTA.4-3.beta.-hydroxysteroids.

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页码：467 / 476

页数：10

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