I-17 TRANSLOCATIONS AND OTHER CHROMOSOME-17 REARRANGEMENTS IN HUMAN PRIMARY NEUROBLASTOMA TUMORS AND CELL-LINES

被引：134
作者：
VANROY, N
LAUREYS, G
CHENG, NC
WILLEM, P
OPDENAKKER, G
VERSTEEG, R
SPELEMAN, F
机构：
[1] STATE UNIV GHENT HOSP, DEPT MED GENET, B-9000 GHENT, BELGIUM
[2] STATE UNIV GHENT HOSP, DEPT PEDIAT, B-9000 GHENT, BELGIUM
[3] CATHOLIC UNIV LEUVEN, REGA INST MED RES, B-3000 LOUVAIN, BELGIUM
[4] ACAD MED CTR, DEPT HUMAN GENET, AMSTERDAM, NETHERLANDS
[5] UNIV WITWATERSRAND, SCH MED, DEPT HAEMATOL, JOHANNESBURG, SOUTH AFRICA
[6] S AFRICAN INST MED RES, JOHANNESBURG 2000, SOUTH AFRICA
来源：
GENES CHROMOSOMES & CANCER | 1994年 / 10卷 / 02期
关键词：
D O I：
10.1002/gcc.2870100205
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We report on the finding of a t(1;17) in two primary neuroblastomas. Subsequent fluorescence in situ hybridization (FISH) analysis revealed the presence of 1;17 translocations in four out of nine neuroblastoma cell lines. The chromosome I short arm breakpoints were determined using region-specific probes. FISH screening also demonstrated or confirmed the presence of 11;17 translocations in three cell lines and other chromosome 17 rearrangements in those cell lines that did not carry a t(1;17) or t(11;17). Our data extend previous cytogenetic findings and suggest that, in addition to the known involvement of chromosome I, one or more genes on chromosome 17 also play a role in neuroblastoma development. (C) 1994 Wiley-Liss, Inc.
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页码：103 / 114
页数：12
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