LASER-LIGHT INDUCED CHROMOSOME-ABERRATIONS IN CHINESE-HAMSTER CELLS

被引：0
|
作者：
VIRSIKPEUCKERT, P [1 ]
HILLRICHS, G [1 ]
NEU, W [1 ]
HARDER, D [1 ]
机构：
[1] LASER LAB GOTTINGEN EV,W-3400 GOTTINGEN,GERMANY
来源：
PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1993年 / 57卷 / 03期
关键词：
D O I：
10.1111/j.1751-1097.1993.tb02336.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Wild-type Chinese hamster cells CHO K1 and their radiosensitive mutant xrs5 were irradiated at 308 nm, using light pulses of a XeCl excimer laser with total energy fluences of 0.1 kJ/m2 to 4.08 kJ/m2. Chromosome-type and chromatid-type chromosome aberrations have been observed at pulse irradiances of 2.5 x 10(7) W/m2 and 1.7 x 10(8) W/m2, indicating that in mammalian cells DNA double-strand breaks occur already in this irradiance range. The results obtained with laser irradiation are compared with X-ray irradiation.
引用
收藏
页码：577 / 579
页数：3
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