EFFECT OF PROSTAGLANDIN-F2-ALPHA ON TRANSMURAL POTENTIAL DIFFERENCE AND SHORT-CIRCUIT CURRENT IN ISOLATED FROG (RANA-CATESBEIANA) SKIN

1. Addition of prostaglandin F2alpha to the inside bathing solution elicited sustained decreases in transmural potential difference and short-circuit current. 2. Addition of indomethacin to the inside bathing solution partially inhibited transmural potential difference and short-circuit current. 3. Addition of indomethacin to the inside bathing solution further decreased the prostaglandin F2alpha effect on transmural potential difference and short-circuit current. 4. The prostaglandin F2alpha-induced effects on short-circuit current were carried by a net active sodium transfer from the outside to the inside bathing solution.