EFFECT OF PLASMODIUM-YOELII INFECTION ON GABA-METABOLISM OF MOUSE-BRAIN

被引：6

作者：

SHARMA, MC ^{[1
]}

TRIPATHI, LM ^{[1
]}

DUTTA, GP ^{[1
]}

SAGAR, P ^{[1
]}

PANDEY, VC ^{[1
]}

机构：

[1] CENT DRUG RES INST,DIV MICROBIOL,LUCKNOW 226001,UTTAR PRADESH,INDIA

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 1990年 / 52卷 / 02期

关键词：

D O I：

10.1016/0014-4800(90)90009-3

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Plasmodium yoelii infection in albino mice decreased the activity of brain glutamic acid decarboxylase (GAD) by about 30 and 48% in crude homogenate and its synaptosomal fraction, respectively. The decrease was evident from 20% parasitemia and remained more or less constant up to 80% parasitemia. The Km values of GAD in normal and infected animals were 1.2 × 10-2 and 3.3 × 10-2 mM, respectively, indicating a decrease in enzyme substrate affinity due to infection. The lowered GAD activity rose to slightly above normal by treatment of infected animals with chloroquine. Decrease in GAD activity reflected lower γ-aminobutyric acid (GABA) levels in the infected brain; however, GABA-transaminase activity was not significantly influenced by infection. It has been proposed that impaired GABA synthesis may be due to hypoxia induced by malarial infection. © 1990.

引用

页码：243 / 248

页数：6

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