PHARMACOKINETICS OF METHADONE DURING MAINTENANCE THERAPY - PULSE LABELING WITH DEUTERATED METHADONE IN THE STEADY-STATE

被引：34

作者：

ANGGARD, E

NILSSON, MI

HOLMSTRAND, J

GUNNE, LM

机构：

[1] UNIV UPPSALA,FAC PHARM,S-75105 UPPSALA,SWEDEN

[2] KAROLINSKA INST,DEPT ALCOHOL & DRUG ADDICT RES,S-10401 STOCKHOLM 60,SWEDEN

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1979年 / 16卷 / 01期

关键词：

mass fragmentography; methadone; pharmacokinetics; pulse labeling;

D O I：

10.1007/BF00644967

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A technique is presented for study of steady state kinetics of methadone using pulse labeling with deuterated methadone (d3) and mass fragmentography to measure both unlabeled and labeled methadone in blood. Seven subjects maintained on methadone for at least 10 months were admitted to a closed metabolic ward. The daily dose of unlabeled methadone (d0) was substituted by one dose of methadone-d3 and plasma levels of methadone-d0 and methadone-d3 were followed for 48 h using a precise (SD±5%) and sensitive (30 pmol/ml) mass fragmentographic technique. Plasma half-lives (t1/2) for both methadone-d0 and metadone-d3 were calculated from samples obtained 8-24 h following the dose of methadone-d3. The t1/2 of oral methadone-d3 was shorter (22±2 h) than that of methadone-d0 (52±20 h). The same pattern was observed after intravenous administration. The results indicate multiple pools of methadone in the body. © 1979 Springer-Verlag.

引用

页码：53 / 57

页数：5

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