METABOLISM OF 16ALPHA-ETHYLPROGESTERONE BY RAT LIVER IN VITRO

被引：0
|
作者：
STENLAKE, JB
TEMPLETON, R
TAYLOR, DC
机构：
[1] Drug Metabolism Unit, Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, University of Strathclyde, Glasgow
来源：
JOURNAL OF PHARMACY AND PHARMACOLOGY | 1968年 / S 20卷
关键词：
D O I：
10.1111/j.2042-7158.1968.tb09876.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The metabolism of 16α‐ethylprogesterone by rat liver homogenate at different steroid to tissue ratios has been examined. The products, identified by thin‐layer chromatography, gas‐liquid chromatography and combined gas‐liquid chromatography‐mass spectrometry were 16α‐ethyl‐5α‐pregnane‐3, 20‐dione and 16α‐ethyl‐3α‐hydroxy‐5α‐pregnan‐20‐one. The yield of these metabolites was 14 and 48% respectively. The results are discussed in relation to the liver in vitro metabolism of progesterone and 16α‐hydroxyprogesterone. 1968 Royal Pharmaceutical Society of Great Britain
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页码：S142 / +
页数：1
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