AMIDE BOND FORMATION VIA PENTAFLUOROTHIOPHENYL ACTIVE ESTERS

被引：21
作者：
DAVIS, AP
WALSH, JJ
机构：
[1] Department of Chemistry, Trinity College, Dublin
来源：
TETRAHEDRON LETTERS | 1994年 / 35卷 / 27期
关键词：
D O I：
10.1016/S0040-4039(00)76989-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A number of pentafluorothiophenyl (PFTP) esters were shown to be useful acyl donors for amide bond formation, being non-polar, stable to chromatography and extended storage, but sufficiently active for use with relatively unreactive acyl groups. In particular, the synthesis of amide 4 via PFTP ester 5 proved superior to a range of alternative methods, including the use of the analogous pentafluorophenyl active ester 3.
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页码：4865 / 4868
页数：4
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