DIFFERENT CONDITIONS FOR GENERATION OF NONCYTOTOXIC AUTORESTRICTED CD4-CD8+ HUMAN SUPPRESSOR T-CELLS AND ALLOSPECIFIC CYTOTOXIC LYMPHOCYTES-T IN ONE-WAY MIXED LYMPHOCYTE-CULTURES - THE ROLE OF ADHERENT MONONUCLEAR-CELLS

被引：1

作者：

BALASHOV, KE ^{[1
]}

BRONDZ, BD ^{[1
]}

机构：

[1] ALL UNION CANC RES CTR,MOSCOW,USSR

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1991年 / 34卷 / 05期

关键词：

D O I：

10.1111/j.1365-3083.1991.tb01590.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The purpose of the present study was to investigate the role of adherent mononuclear cells (AMC) in generation of suppressor T lymphocytes (T-Lph) in one-way allogeneic mixed lymphocyte cultures (MLC). Alloantigen-specific cytotoxic T-Lph were generated in MLC predominantly in the presence of stimulator AMC, but not responder AMC. The presence of responder AMC and the absence of stimulator AMC were optimal conditions for generation of non-cytotoxic (through the whole duration of MLC) suppressor T-Lph. These CD4-CD8+ suppressor T-Lph were allononspecific but autorestricted (with responders in test MLC).

引用

页码：667 / 671

页数：5

共 19 条

[1]

BALASHOV KE, 1987, EKSP ONKOL, V9, P48

[2]

BRONDZ BD, 1991, EKSP ONKOL, V13, P10

[3]

DAMLE NK, 1985, J IMMUNOL, V135, P1724

[4] IMMUNOREGULATORY T-CELL CIRCUITS IN MAN - ALLOANTIGEN-PRIMED INDUCER T-CELLS ACTIVATE ALLOANTIGEN-SPECIFIC SUPPRESSOR T-CELLS IN THE ABSENCE OF THE INITIAL ANTIGENIC STIMULUS [J].