IN-VITRO STUDIES ON THE IMMUNOMODULATING EFFECTS OF POLYPODIUM-LEUCOTOMOS EXTRACT ON HUMAN-LEUKOCYTE FRACTIONS

被引：0

作者：

BERND, A

RAMIREZBOSCA, A

HUBER, H

ALPERI, JD

THACI, D

SEWELL, A

ALMAGRO, EQ

HOLZMANN, H

机构：

[1] UNIV VALENCIA, FAC MED, SERV DERMATOL, VALENCIA, SPAIN

[2] ASAC PHARMACEUT INT AIE, ALACANT, SPAIN

[3] UNIV MAINZ, UNIV KLIN, MAINZ, GERMANY

[4] UNIV FRANKFURT KLINIKUM, ZENTRUM KINDERHEILKUNDE, ALLGEMEINE PADIAT ABT 1, FRANKFURT, GERMANY

来源：

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH | 1995年 / 45-2卷 / 08期

关键词：

ANAPSOS(R); IN VITRO STUDIES; CALAGUALINE; IMMUNOMODULATORS; POLYPODIUM LEUCOTOMOS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The in vitro effect of Anapsos(R), a water based extract of the naturally occurring fern Polypodium leucotomos (calagualine), on human leukocyte fractions was investigated. Calagualine inhibited interleukin-2 secretion and concanavalin A (Con A) stimulated proliferation of T-lymphocytes in a concentration dependent manner. In contrast, a greatly enhanced secretion of IL-1 alpha, IL-1 beta and tumor necrosis factor a was induced suggesting a stimulation of monocytes and dendritic cells also present in this system. Endotoxin induced stimulation was excluded. Also in the absence of Con A, calagualine stimulated cytokine production. The presented data show for the first time that calagualine exerts an immunomodulating effect on leukocyte fractions, paving the way for further detailed studies related to possible clinical efficacy.

引用

页码：901 / 904

页数：4

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