WIEDENDIOL-A AND WIEDENDIOL-B, CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS FROM THE MARINE SPONGE XESTOSPONGLIA-WIEDENMAYERI

被引：65

作者：

COVAL, SJ ^{[1
]}

CONOVER, MA ^{[1
]}

MIERZWA, R ^{[1
]}

KING, A ^{[1
]}

PUAR, MS ^{[1
]}

机构：

[1] HARBOR BRANCH OCEANOG INST INC,FT PIERCE,FL 34946

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 06期

关键词：

D O I：

10.1016/0960-894X(95)00081-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Wiedendiol-A and -B, novel sesquiterpene-hydroquinones which inhibit cholesteryl ester transfer protein (CETP), have been isolated form the marine sponge Xestospongia wiedenmayeri. Additional related marine natural products were also evaluated for CETP inhibition. Compounds that inhibit the activity of CETP may find utility as antiatherosclerosis therapy.

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页码：605 / 610

页数：6

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