HISTIOCYTIC CYTOPHAGIC PANNICULITIS - MOLECULAR EVIDENCE FOR A CLONAL T-CELL DISORDER

被引：36

作者：

HYTIROGLOU, P

PHELPS, RG

WATTENBERG, DJ

STRAUCHEN, JA

机构：

[1] CUNY MT SINAI SCH MED,DEPT DERMATOL,NEW YORK,NY 10029

[2] CUNY MT SINAI SCH MED,DEPT PATHOL,NEW YORK,NY 10029

[3] CUNY MT SINAI SCH MED,DEPT NEOPLAST DIS,NEW YORK,NY 10029

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1992年 / 27卷 / 02期

关键词：

D O I：

10.1016/0190-9622(92)70194-K

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Histiocytic cytophagic panniculitis is a systemic disease of unknown etiopathogenesis that invariably involves the subcutaneous fat and is histologically characterized by phagocytosis of blood elements by histiocytes that appear to be benign. Immunophenotypic and genotypic studies of biopsy specimens of the lesions of a 58-year-old woman showed that the lymphocytic infiltrates accompanying the histiocytes in the subcutis were composed of clonal T-cells with rearrangement of the surface receptor gene. Our findings suggest that the primary abnormality in histiocytic cytophagic panniculitis may be a clonal T-cell proliferation.

引用

页码：333 / 336

页数：4

共 18 条

[1] HISTIOCYTIC CYTOPHAGIC PANNICULITIS [J].