SEQUENTIAL RELEASE OF ANTIGENS FROM CHLOROFORM-TREATED STAPHYLOCOCCUS-EPIDERMIDIS - APPLICATION TOWARDS A POSSIBLE VACCINE

被引：2
作者：
AHMAD, A
CLARKE, S
BUCHAN, A
SKINNER, GRB
机构：
[1] Department of Medical Microbiology, Medical School, University of Birmingham, Birmingham, B15 2TJ, Edgbaston
来源：
JOURNAL OF APPLIED BACTERIOLOGY | 1990年 / 69卷 / 05期
关键词：
D O I：
10.1111/j.1365-2672.1990.tb01562.x
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Ahmad, A., Clarke, S., Buchan, A. & Skinner, G.R.B. 1990. Sequential release of antigens from chloroform‐treated Staphylococcus epidermidis: application towards a possible vaccine. Journal of Applied Bacteriology69, 676–685. This study describes the properties of two potential Staphylococcus epidermidis vaccines prepared by chloroform treatment of bacteria and release of antigen from these chloroform‐treated organisms. Both vaccines were antigenic on testing with homologous hyperimmune serum and induced immune reactivity in immunized rabbits. There was protective efficacy in mice against intraperitoneal challenge by Staph, epidermidis. Copyright © 1990, Wiley Blackwell. All rights reserved
引用
收藏
页码：676 / 685
页数：10
相关论文
共 23 条
[1]   SIMPLE, RAPID, AND QUANTITATIVE RELEASE OF PERIPLASMIC PROTEINS BY CHLOROFORM [J].
AMES, GF ;
PRODY, C ;
KUSTU, S .
JOURNAL OF BACTERIOLOGY, 1984, 160 (03) :1181-1183
[2]  
BINT AJ, 1987, LANCET, V1, P845
[3]  
BURNETTE WN, 1981, ANAL BIOCHEM, V112, P195, DOI 10.1016/0003-2697(81)90281-5
[4]  
Christensen G D, 1987, Adv Intern Med, V32, P177
[5]   STAPHYLOCOCCUS-EPIDERMIDIS - A SIGNIFICANT NOSOCOMIAL PATHOGEN [J].
HAMORY, BH ;
PARISI, JT .
AMERICAN JOURNAL OF INFECTION CONTROL, 1987, 15 (02) :59-74
[6]   NEW METHOD FOR PREPARATION AND SOME PROPERTIES OF STAPHYLOCOCCAL DELTA-HEMOLYSIN [J].
HEATLEY, NG .
JOURNAL OF GENERAL MICROBIOLOGY, 1971, 69 (DEC) :269-&
[7]   PROTEINS SPECIFIED BY HERPES-SIMPLEX VIRUS .2. VIRION POLYPEPTIDES OF TYPE 1 STRAINS [J].
HEINE, JW ;
HONESS, RW ;
CASSAI, E ;
ROIZMAN, B .
JOURNAL OF VIROLOGY, 1974, 14 (03) :640-651
[8]   THE RELATIONSHIP OF CAPSULAR-TYPE OF STAPHYLOCOCCUS-EPIDERMIDIS TO VIRULENCE AND INDUCTION OF RESISTANCE IN THE MOUSE [J].
ICHIMAN, Y ;
YOSHIDA, K .
JOURNAL OF APPLIED BACTERIOLOGY, 1981, 51 (02) :229-241
[9]   EXPERIMENTAL STAPHYLOCOCCAL INFECTIONS IN NEWBORN MICE - INHIBITION OF WEIGHT-GAIN AS AN INDEX OF VIRULENCE [J].
KINSMAN, OS ;
ARBUTHNOTT, JP .
JOURNAL OF MEDICAL MICROBIOLOGY, 1980, 13 (02) :281-290
[10]   STAPHYLOCOCCI IN THE UK - A REVIEW [J].
LACEY, RW ;
KEYWORTH, N ;
LINCOLN, C .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1984, 14 :19-25
123