AUTOMATED DETERMINATION OF ASCORBIC ACID IN MULTIVITAMIN PREPARATIONS

被引：7

作者：

GELLER, M

WEBER, OWA

SENKOWSKI, BZ

机构：

[1] Analytical Research Laboratories, Hoffmann-La Roche Inc., Nutley, New Jersey

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 04期

关键词：

Ascorbic acid in multivitamin products—automated analysis; Automated procedure—ascorbic acid analysis; Colorimetric analysis—spectrophotometer; Schematic diagram—ascorbic acid automated analysis;

D O I：

10.1002/jps.2600580420

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A specific colorimetric method for the determination of ascorbic acid in multivitamin preparations has been automated. The method is based on the coupling reaction of diazotized 4‐methoxy‐2‐nitroaniline with ascorbic acid. A bathochromic shift in the chromophore is effected by the addition of alkali. The stable blue color developed is measured at 570 μ. Application of the automated procedure for the determination of ascorbic acid in multivitamin and mineral preparations is described. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：477 / +

页数：1

共 6 条

[1] KOHOURY AJ, 1967, AUTOMATION ANALYTICA, P286
[2] PELLETIE.O, 1966, J ASSOC OFF ANA CHEM, V49, P800
[3] ROBINSON WB, 1945, J BIOL CHEM, V160, P217
[4] Roe JH, 1943, J BIOL CHEM, V147, P399
[5] COLORIMETRIC DETERMINATION OF ASCORBIC ACID - NEW DEVELOPMENTS CONCERNING THE REACTION WITH DIAZOTIZED 4-METHOXY-2-NITROANILINE
SCHMALL, M
PIFER, CW
WOLLISH, EG
DUSCHINSKY, R
GAINER, H
[J]. ANALYTICAL CHEMISTRY, 1954, 26 (09) : 1521 - 1522
[6] DETERMINATION OF ASCORBIC ACID BY A NEW COLORIMETRIC REACTION
SCHMALL, M
PIFER, CW
WOLLISH, EG
[J]. ANALYTICAL CHEMISTRY, 1953, 25 (10) : 1486 - 1490

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