CAROTENOIDS, RETINOL, AND VITAMIN-E AND RISK OF PROLIFERATIVE BENIGN BREAST DISEASE AND BREAST-CANCER

被引：78

作者：

LONDON, SJ

STEIN, EA

HENDERSON, IC

STAMPFER, MJ

WOOD, WC

REMINE, S

DMOCHOWSKI, JR

ROBERT, NJ

WILLETT, WC

机构：

[1] Department of Preventive Medicine, University of Southern California, Los Angeles, CA

[2] Medical Research Laboratories, Cincinnati, OH

[3] Dana Farber Cancer Center and the Department of Medicine, Harvard Medical School, Boston, MA

[4] Department of Epidemiology, Harvard School of Public Health, Boston, MA

[5] Department of Survery, Massachusetts General Hospital, Boston, MA

[6] Department of Surgery, Labey Clinic, Burlington, MA

[7] Department of Surgery, Labey Clinic, Burlington, MA

[8] Department of Medicine, New England Medical Center, Tufts University, Boston, MA

[9] Channing Laboratory, Department of Medicine at Brigham and Women's Hospital, Harvard Medical School, Boston, MA

[10] Department of Nutrition, Harvard School of Public Health, Boston, MA

来源：

CANCER CAUSES & CONTROL | 1992年 / 3卷 / 06期

关键词：

ALPHA-CAROTENE; ALPHA-TOCOPHEROL; BENIGN BREAST DISEASE; BETA-CAROTENE; BREAST CANCER; DIETARY INTAKE; GAMMA-TOCOPHEROL; LYCOPENE; SERUM; UNITED-STATES;

D O I：

10.1007/BF00052746

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the relationship between serum levels of retinol, beta-carotene, alpha-carotene, lycopene, alpha-tocopherol, and gamma-tocopherol as well as intakes of retinol, carotene, and vitamin E and the risks of breast cancer and proliferative benign breast disease (BBD) in a case-control study of postmenopausal women in the Boston, MA (United States) area. Serum nutrient data were available for 377 women with newly diagnosed stage I or 11 breast cancer and 173 women with proliferative BBD. Controls were 403 women who were evaluated at the same institutions but did not require a breast biopsy or whose biopsy revealed nonproliferative BBD. We observed no significant associations between serum levels of these micronutrients and risk of proliferative BBD or breast cancer. The risk of breast cancer was decreased among women in the highest quintile of intake of vitamin E from food sources only (odds ratio [OR] for the highest quintile = 0.4, 95 percent confidence interval [CI] = 0.2-0.9; P, trend across quintiles = 0.02) but less so for total vitamin E intake including supplements (OR = 0.7, CI = 0.4-1.3; P, trend = 0.07).

引用

页码：503 / 512

页数：10

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