GLUCOSE OVER-UTILIZATION IN DIABETES - EVIDENCE FROM STUDIES ON THE CHANGES IN HEXOKINASE, THE PENTOSE-PHOSPHATE PATHWAY AND GLUCURONATE-XYLULOSE PATHWAY IN RAT-KIDNEY CORTEX IN DIABETES

被引：44

作者：

SOCHOR, M

BAQUER, NZ

MCLEAN, P

机构：

[1] Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School, London

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 86卷 / 01期

关键词：

D O I：

10.1016/0006-291X(79)90378-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Kidney cortex from alloxan-diabetic rats has an elevated activity of hexokinase, enzymes of the pentose phosphate pathway and of certain enzymes of the glucuronate-xylulose route relative to age-matched control rats. These changes are highly significant when expressed as total kidney units/100 g body weight, a parameter relating biochemical activity to the functional requirement of the whole animal. These changes are discussed in relation to the hypothesis of 'glucose over-utilization' in diabetes in tissues not requiring insulin for glucose uptake [R.G. Spiro (1976) Diabetologia 12, 1-14]. © 1979.

引用

页码：32 / 39

页数：8

共 29 条

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