BRAIN GRAFTS REDUCE MOTOR ABNORMALITIES PRODUCED BY DESTRUCTION OF NIGROSTRIATAL DOPAMINE SYSTEM

被引：778

作者：

PERLOW, MJ

FREED, WJ

HOFFER, BJ

SEIGER, A

OLSON, L

WYATT, RJ

机构：

[1] KAROLINSKA INST,DEPT HISTOL,S-10401 STOCKHOLM 60,SWEDEN

[2] UNIV COLORADO,SCH MED,DEPT PHARMACOL,DENVER,CO 80262

来源：

SCIENCE | 1979年 / 204卷 / 4393期

关键词：

D O I：

10.1126/science.571147

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In order to determine if brain tissue grafts can provide functional input to recipient central nervous system tissue, fetal rat dopamine-containing neurons were implanted adjacent to the caudate nucleus of adult recipients whose endogenous dopaminergic input had been destroyed. The grafts showed good survival and axonal outgrowth. Motor abnormalities, which had been induced by the destruction of the endogenous dopaminergic input to the caudate, were significantly reduced after grafting of the fetal brain tissue. These data suggest that such implants may be potentially useful in reversing deficits after circumscribed destruction of brain tissue. Copyright © 1979 AAAS.

引用

页码：643 / 647

页数：5

共 41 条

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