A NEW SYNTHESIS OF DEGLYCO-BLEOMYCIN-A2 AIMING AT THE TOTAL SYNTHESIS OF BLEOMYCIN

被引：23
作者：
SAITO, SI
UMEZAWA, Y
MORISHIMA, H
TAKITA, T
UMEZAWA, H
NARITA, M
OTSUKA, M
KOBAYASHI, S
OHNO, M
机构：
[1] INST MICROBIAL CHEM,SHINAGAWA KU,TOKYO 141,JAPAN
[2] UNIV TOKYO,FAC PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN
来源：
TETRAHEDRON LETTERS | 1982年 / 23卷 / 05期
关键词：
D O I：
10.1016/S0040-4039(00)86880-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
引用
收藏
页码：529 / 532
页数：4
相关论文
共 6 条
[1]   CHEMISTRY OF BLEOMYCIN .28. PREPARATION OF DEGLYCO-BLEOMYCIN BY MILD ACID-HYDROLYSIS OF BLEOMYCIN [J].
MURAOKA, Y ;
SUZUKI, M ;
FUJII, A ;
UMEZAWA, Y ;
NAGANAWA, H ;
TAKITA, T ;
UMEZAWA, H .
JOURNAL OF ANTIBIOTICS, 1981, 34 (03) :353-357
[2]   CHEMISTRY OF BLEOMYCIN .6. SELECTIVE CLEAVAGE OF BLEOMYCIN A2 BY N-BROMOSUCCINIMIDE [J].
MURAOKA, Y ;
UMEZAWA, H ;
TAKITA, T ;
MAEDA, K .
JOURNAL OF ANTIBIOTICS, 1972, 25 (03) :185-&
[3]   STEREOSELECTIVE SYNTHESIS OF (2S,3S,4R)-4-AMINO-3-HYDROXY-2-METHYL-PENTANOIC ACID, AN AMINO-ACID CONSTITUENT OF BLEOMYCIN, BY ALDOL CONDENSATION [J].
NARITA, M ;
OTSUKA, M ;
KOBAYASHI, S ;
OHNO, M ;
UMEZAWA, Y ;
MORISHIMA, H ;
SAITO, SI ;
TAKITA, T ;
UMEZAWA, H .
TETRAHEDRON LETTERS, 1982, 23 (05) :525-528
[4]   TOTAL SYNTHESIS OF BLEOMYCIN-A2 [J].
TAKITA, T ;
UMEZAWA, Y ;
SAITO, SI ;
MORISHIMA, H ;
NAGANAWA, H ;
UMEZAWA, H ;
TSUCHIYA, T ;
MIYAKE, T ;
KAGEYAMA, S ;
UMEZAWA, S ;
MURAOKA, Y ;
SUZUKI, M ;
OTSUKA, M ;
NARITA, M ;
KOBAYASHI, S ;
OHNO, M .
TETRAHEDRON LETTERS, 1982, 23 (05) :521-524
[5]   TOTAL SYNTHESIS OF DEGLYCO-BLEOMYCIN-A2 [J].
TAKITA, T ;
UMEZAWA, Y ;
SAITO, S ;
MORISHIMA, H ;
UMEZAWA, H ;
MURAOKA, Y ;
SUZUKI, M ;
OTSUKA, M ;
KOBAYASHI, S ;
OHNO, M .
TETRAHEDRON LETTERS, 1981, 22 (07) :671-674
[6]   SYNTHESIS OF THE PYRIMIDINE MOIETY OF BLEOMYCIN [J].
UMEZAWA, Y ;
MORISHIMA, H ;
SAITO, S ;
TAKITA, T ;
UMEZAWA, H ;
KOBAYASHI, S ;
OTSUKA, M ;
NARITA, M ;
OHNO, M .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (21) :6630-6631
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