Refractory Duodenal Crohn's Disease Successfully Treated with Infliximab

被引：7

作者：

Kim, You Lim ^{[1
]}

Park, Young Sook ^{[1
]}

Park, Eun Kyoung ^{[1
]}

Park, Dae Rim ^{[1
]}

Choi, Gyu Sik ^{[1
]}

Ahn, Sang Bong ^{[1
]}

Kim, Seong Hwan ^{[1
]}

Jo, Yun Ju ^{[1
]}

机构：

[1] Eulji Univ, Sch Med, Eulji Med Ctr, Dept Internal Med, Seoul, South Korea

来源：

INTESTINAL RESEARCH | 2014年 / 12卷 / 01期

关键词：

Crohn's disease; Duodenum; Infliximab;

D O I：

10.5217/ir.2014.12.1.66

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Crohn's disease (CD) may involve any part of the gastrointestinal tract, from the mouth to the anus. Approximately >90% of cases occur in the small bowel and colon. Upper gastrointestinal involvement, especially duodenal manifestation, is relatively rare. Therefore, adequate medical treatment for duodenal CD has not yet been established. We report a case of CD with duodenal involvement. A 46-year-old man with Crohn's ileocolitis presented to our hospital with right upper quadrant pain. An endoscopy showed a deep excavated ulcer with deformity at the duodenal bulb, and he was initially treated with azathioprine (1 mg/kg), Pentasa (3.0 g/day), and a proton pump inhibitor for 1 year. However, the deep ulcer did not heal. Therefore, infliximab infusion therapy was initiated, and the duodenal lesion completely resolved on follow-up esophagogastroduodenoscopy. We report a case of duodenal CD that completely resolved following infliximab infusion, with a review of the literature.

引用

页码：66 / 69

页数：4