DETERMINATION OF 2-THIOTHIAZOLIDINE-4-CARBOXYLIC ACID IN URINE BY LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION

被引：11
作者：
CIUCU, A
BALDWIN, RP
机构：
[1] UNIV LOUISVILLE,DEPT CHEM,LOUISVILLE,KY 40292
[2] UNIV BUCHAREST,DEPT ANALYT CHEM,BUCHAREST,ROMANIA
来源：
ELECTROANALYSIS | 1992年 / 4卷 / 04期
关键词：
AMPEEROMETRIC DETECTION; 2-THIOTHIAZOLIDINE-4-CARBOXYLIC ACID; MODIFIED ELECTRODE;
D O I：
10.1002/elan.1140040420
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
An assay procedure utilizing liquid chromatography and amperometric detection at a chemically modified electrode (CME) has been developed for the determination of 2-thiothiazolidine-4-carboxylic acid (TTCA) in urine samples. The electrocatalytic activity of the CME, which consisted of a glassy carbon surface coated with an electropolymerized cobalt phthalocyanine film, permitted optimum response at a potential of +0.75 V vs. Ag/AgCl with a detection limit of 7 pmol for TTCA and with no sample preparation required. In case of fouling of the electrode surface by sample constituents, the polymeric cobalt phthalocyanine electrode surface could be renewed with a variability of less than 10% and an equilibration time of less than 15 minutes.
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收藏
页码：515 / 519
页数：5
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