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TAURINE MODULATES ION INFLUX THROUGH CARDIAC CA-2+ CHANNELS
被引:41
|
作者
:
SAWAMURA, A
论文数:
0
引用数:
0
h-index:
0
机构:
OSAKA UNIV,SCH MED,DEPT INTERNAL MED 3,1-1-50 FUKUSHIMA,FUKUSHIMA KU,OSAKA 553,JAPAN
SAWAMURA, A
SADA, H
论文数:
0
引用数:
0
h-index:
0
机构:
OSAKA UNIV,SCH MED,DEPT INTERNAL MED 3,1-1-50 FUKUSHIMA,FUKUSHIMA KU,OSAKA 553,JAPAN
SADA, H
AZUMA, J
论文数:
0
引用数:
0
h-index:
0
机构:
OSAKA UNIV,SCH MED,DEPT INTERNAL MED 3,1-1-50 FUKUSHIMA,FUKUSHIMA KU,OSAKA 553,JAPAN
AZUMA, J
KISHIMOTO, S
论文数:
0
引用数:
0
h-index:
0
机构:
OSAKA UNIV,SCH MED,DEPT INTERNAL MED 3,1-1-50 FUKUSHIMA,FUKUSHIMA KU,OSAKA 553,JAPAN
KISHIMOTO, S
SPERELAKIS, N
论文数:
0
引用数:
0
h-index:
0
机构:
OSAKA UNIV,SCH MED,DEPT INTERNAL MED 3,1-1-50 FUKUSHIMA,FUKUSHIMA KU,OSAKA 553,JAPAN
SPERELAKIS, N
机构
:
[1]
OSAKA UNIV,SCH MED,DEPT INTERNAL MED 3,1-1-50 FUKUSHIMA,FUKUSHIMA KU,OSAKA 553,JAPAN
[2]
UNIV YAMAGUCHI,COLL MED,DEPT PHARMACOL,UBE,JAPAN
[3]
UNIV CINCINNATI,COLL MED,DEPT PHYSIOL & BIOPHYS,CINCINNATI,OH 45221
来源
:
CELL CALCIUM
|
1990年
/ 11卷
/ 04期
关键词
:
D O I
:
10.1016/0143-4160(90)90001-B
中图分类号
:
Q2 [细胞生物学];
学科分类号
:
071009 ;
090102 ;
摘要
:
The effects of taurine on the inward Ca2+ current (ICa) were investigated by means of the whole-cell voltage-clamp technique in isolated single guinea pig ventricular myocytes. ICa were elicited by 200-ms test pulses from a conditioning holding potential of -45 mV to various test potentials at a rate of 0.5 Hz. Taurine (10-20 mM) had different effects on ICa, depending on the extracellular Ca2+ concentration ([Ca]0). A small stimulatory effect of taurine was found in low [Ca]0 (0.8 mM), and a small inhibitory effect was found in high [Ca]0 (3.6 mM). Taurine had no significant effect on ICa in normal [Ca]0 (1.8 mM). Such dual effects on ICa may explain the various effects reported for taurine, especially its dual inotropic actions on cardiac muscle depending upon [Ca]0. Thus, taurine acts in a manner to keep ICa relatively constant. Taurine increased the resting potential irrespective of [Ca]0, suggesting that, in addition, taurine increased K+ conductance and/or ion exchange systems such as the Na Ca and Na K exchange. © 1990.
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页码:251 / 259
页数:9
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