HOMOVANILLIC ACID AND 5-HYDROXYINDOLEACETIC ACID IN CEREBROSPINAL FLUID OF PATIENTS WITH SENILE DEMENTIA, PRESENILE DEMENTIA AND PARKINSONISM

被引：165

作者：

GOTTFRIES, CG

GOTTFRIES, I

ROOS, BE

机构：

[1] Östra Sjukhuset, Malmö

[2] Department of Psychiatry II, University of Lund

[3] Department of Pharmacolog, University of Göteborg

来源：

JOURNAL OF NEUROCHEMISTRY | 1969年 / 16卷 / 09期

关键词：

D O I：

10.1111/j.1471-4159.1969.tb05984.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— Four groups, one of healthy volunteers, one of senile dementia, one of presenile dementia, and one of patients with parkinsonism were compared according to the values of HVA and 5‐HIAA in CSF. The levels of HVA and 5‐HIAA were highest in the group of healthy volunteers and decreased in the following order: senile dementia, presenile dementia, and parkinsonism. In the groups the two metabolites were positively correlated. These results are in agreement with earlier investigations showing disturbances of monoamine metabolism in the brain of patients suffering from these syndromes. Copyright © 1969, Wiley Blackwell. All rights reserved

引用

页码：1341 / +

页数：1

共 20 条

[1]

ANDEN NE, 1963, LIFE SCI, V7, P448

[2] EFFECT OF PROBENECID ON ELIMINATION FROM CSF OF INTRAVENTRICULARY INJECTED 5-HYDROXYINDOLEACETIC ACID IN NORMAL AND HYDROCEPHALIC DOGS [J].