IMMUNODEFICIENCY IN IL-2-KNOCKOUT MICE

被引：37
作者：
HORAK, I
机构：
[1] Institute of Virology and Immunobiology, University of Wuärzburg, D 97078 Wuärzburg
来源：
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1995年 / 76卷 / 03期
关键词：
D O I：
10.1016/S0090-1229(95)90126-4
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interleukin-2-deficient mice (IL-2(-/-)) generated by targeted mutagenesis proved to be an excellent system to study the function of this lymphokine in the context of whole immune system. In addition, they provide an animal model of a primary immunodeficiency caused by a single-gene defect. Our results indicate that the essential degect in IL-2(-/-) mice is the lack of a negative regulatory function, which leads to breakdown of self tolerance. The development of autoimmune diseases in IL-2-deficient mice stresses the link between autoimmunity and primary immunodeficiencies. (C) 1995 Academic Press, Inc.
引用
收藏
页码：S172 / S173
页数：2
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