POLYMORPHISM OF TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) AT POSITION -308 IN RELATION TO ANKYLOSING-SPONDYLITIS

被引：0
|
作者：
VERJANS, GMGM
BRINKMAN, BMN
VANDOORNIK, CEM
KIJLSTRA, A
VERWEIJ, CL
机构：
[1] LEIDEN UNIV,DEPT RHEUMATOL,LEIDEN,NETHERLANDS
[2] UNIV AMSTERDAM,ACAD MED CTR,DEPT OPHTHALMOL,1105 AZ AMSTERDAM,NETHERLANDS
来源：
CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 1994年 / 97卷 / 01期
关键词：
HLA-B27; ACUTE ANTERIOR UVEITIS; ANKYLOSING SPONDYLITIS; TUMOR NECROSIS FACTOR-ALPHA; ALLELE SPECIFIC POLYMERASE CHAIN REACTION;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In addition to HLA-B27, other genetic factors are thought to be involved in the pathogenesis of ankylosing spondylitis (AS). Because of the localization, in the proximity of the HLA-B locus, and the biological activities of TNF-alpha, we investigated the association between AS and a single base polymorphism located at position -308 of the TNF-alpha gene. An allele-specific polymerase chain reaction was developed to monitor this polymorphism. The frequency of the TNF-alpha alleles was determined in 66 AS patients and 37 healthy controls. The TNF-alpha allele frequency was not significantly different between AS patients and controls.
引用
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页码：45 / 47
页数：3
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