POLYMORPHISM OF TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) AT POSITION -308 IN RELATION TO ANKYLOSING-SPONDYLITIS

被引：0
作者：
VERJANS, GMGM
BRINKMAN, BMN
VANDOORNIK, CEM
KIJLSTRA, A
VERWEIJ, CL
机构：
[1] LEIDEN UNIV,DEPT RHEUMATOL,LEIDEN,NETHERLANDS
[2] UNIV AMSTERDAM,ACAD MED CTR,DEPT OPHTHALMOL,1105 AZ AMSTERDAM,NETHERLANDS
来源：
CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 1994年 / 97卷 / 01期
关键词：
HLA-B27; ACUTE ANTERIOR UVEITIS; ANKYLOSING SPONDYLITIS; TUMOR NECROSIS FACTOR-ALPHA; ALLELE SPECIFIC POLYMERASE CHAIN REACTION;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In addition to HLA-B27, other genetic factors are thought to be involved in the pathogenesis of ankylosing spondylitis (AS). Because of the localization, in the proximity of the HLA-B locus, and the biological activities of TNF-alpha, we investigated the association between AS and a single base polymorphism located at position -308 of the TNF-alpha gene. An allele-specific polymerase chain reaction was developed to monitor this polymorphism. The frequency of the TNF-alpha alleles was determined in 66 AS patients and 37 healthy controls. The TNF-alpha allele frequency was not significantly different between AS patients and controls.
引用
收藏
页码：45 / 47
页数：3
相关论文
共 15 条
[1]   GUILT BY ASSOCIATION - HLA-B27 AND ANKYLOSING-SPONDYLITIS [J].
BENJAMIN, R ;
PARHAM, P .
IMMUNOLOGY TODAY, 1990, 11 (04) :137-142
[2]   TUMOR NECROSIS, CACHEXIA, SHOCK, AND INFLAMMATION - A COMMON MEDIATOR [J].
BEUTLER, B ;
CERAMI, A .
ANNUAL REVIEW OF BIOCHEMISTRY, 1988, 57 :505-518
[3]  
BREWERTON D, 1990, LANCET, V335, P904
[4]   MAP OF THE HUMAN MHC [J].
CAMPBELL, RD ;
TROWSDALE, J .
IMMUNOLOGY TODAY, 1993, 14 (07) :349-352
[5]  
DERHAAG PJFM, 1989, INVEST OPHTH VIS SCI, V30, P2160
[6]  
Fleiss JL., 1981, STAT METHODS RATES P, V2
[7]   NCOI RESTRICTION FRAGMENT LENGTH POLYMORPHISM (RFLP) OF THE TUMOR NECROSIS FACTOR (TNF-ALPHA) REGION IN PRIMARY BILIARY-CIRRHOSIS AND IN HEALTHY DANES [J].
FUGGER, L ;
MORLING, N ;
RYDER, LP ;
PLATZ, P ;
GEORGSEN, J ;
JAKOBSEN, BK ;
SVEJGAARD, A ;
DALHOFF, K ;
RANEK, L .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1989, 30 (02) :185-189
[8]   HERITABLE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II-ASSOCIATED DIFFERENCES IN PRODUCTION OF TUMOR NECROSIS FACTOR-ALPHA - RELEVANCE TO GENETIC PREDISPOSITION TO SYSTEMIC LUPUS-ERYTHEMATOSUS [J].
JACOB, CO ;
FRONEK, Z ;
LEWIS, GD ;
KOO, M ;
HANSEN, JA ;
MCDEVITT, HO .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (03) :1233-1237
[9]   LOW DEGREE OF DNA POLYMORPHISM IN THE HLA-LINKED LYMPHOTOXIN (TUMOR NECROSIS FACTOR-BETA) GENE [J].
PARTANEN, J ;
KOSKIMIES, S .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1988, 28 (03) :313-316
[10]   HLA-BW60 INCREASES SUSCEPTIBILITY TO ANKYLOSING-SPONDYLITIS IN HLA-B27+ PATIENTS [J].
ROBINSON, WP ;
VANDERLINDEN, SM ;
KHAN, MA ;
RENTSCH, HU ;
CATS, A ;
RUSSELL, A ;
THOMSON, G .
ARTHRITIS AND RHEUMATISM, 1989, 32 (09) :1135-1141
12