INABILITY OF LACTOBACILLUS-CASEI STRAIN GG, L-ACIDOPHILUS, AND BIFIDOBACTERIUM-BIFIDUM TO DEGRADE INTESTINAL MUCUS GLYCOPROTEINS

被引：67

作者：

RUSELERVANEMBDEN, JGH ^{[1
]}

VANLIESHOUT, LMC ^{[1
]}

GOSSELINK, MJ ^{[1
]}

MARTEAU, P ^{[1
]}

机构：

[1] HOP ST LAZARE,GASTROENTEROL UNIT,PARIS,FRANCE

来源：

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | 1995年 / 30卷 / 07期

关键词：

BIFIDOBACTERIUM BIFIDUM; LACTOBACILLUS ACIDOPHILUS; LACTOBACILLUS CASEI GG; MUCUS DEGRADATION;

D O I：

10.3109/00365529509096312

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Lactic acid bacteria have been suggested for use in the prevention of relapse of ulcerative colitis and of recurrent pouchitis. These strains may not damage the protective intestinal mucus glycoproteins. Methods: Lactobacillus casei strain GG and strains isolated from a commercial fermented product (Lactobacillus acidophilus, Bifidobacterium bifidum, and a mesophylic lactic culture) were cultured in vitro on hog gastric mucin and human intestinal glycoproteins. Furthermore, germ-free rats were mono-associated with Lactobacillus GG and poly-associated with the other strains. Glycoproteins were isolated from rat distal ileum, cecum, and colon. Mucus degradation was established by assaying carbohydrates (hexosamines, hexoses, pentoses), proteins, and blood group antigenicity. Results: All strains colonized the intestinal mucus but were not found in the deep crypts. Degradation of mucus glycoproteins was observed neither in vitro nor in vivo. Conclusion: The tested strains do not break down intestinal mucus glycoproteins and thus far are safe to use for therapy.

引用

页码：675 / 680

页数：6

共 34 条

[1] FECAL RECOVERY IN HUMANS OF VIABLE BIFIDOBACTERIUM SP INGESTED IN FERMENTED MILK [J].