Optimization of solid-phase extraction for the liquid chromatography-tandem mass spectrometry analysis of basic drugs in equine urine

被引：0
作者：
Du Shin, Hyun [1 ,2 ]
Yang, Ji Suk [1 ]
Jung, Mihye [2 ]
Kim, Hyung-seung [2 ,3 ]
Youm, Jeong-Rok [2 ]
Hu, Man Bae [1 ]
Kim, Sung Jean [1 ]
Han, Sang Beom [2 ]
机构：
[1] Korea Racing Author, Racing Lab, 685,Juam Dong, Gwacheon 427711, Gyeonggi, South Korea
[2] Chung Ang Univ, Coll Pharm, Seoul 156756, South Korea
[3] Minist Natl Def, Sci Invest Lab Criminal Invest Comm, Seoul 140701, South Korea
来源：
ANALYTICAL SCIENCE AND TECHNOLOGY | 2008年 / 21卷 / 05期
关键词：
Basic drugs; Equine urine; SPE; LC-MS/MS;
D O I：
暂无
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A procedure based on solid-phase extraction (SPE) followed by liquid chromatography-tandem mass spectrometry has been developed for the simultaneous analysis of 55 basic drugs in equine urine. The test scope covers diversified classes of drugs including some beta-blockers, beta-agonists, antihypotensives, CNS stimulants, sedatives, tranquilizers, antidepressants, antihypertensives and so on. LC-MS/ MS separation and quantification was carried out in positive electrospray ionization and multiple reaction monitoring (MRM) mode. Four different brands of mixed mode cation exchange SPE sorbents; UCT XTRACT (R) XRDAH, Supelco DSC-MCAX (R), Varian Bond Elut Certify (R) and Waters Oasis (R) MCX were compared. The UCT XTRACT (R) XRDAH sorbent provided
引用
收藏
页码：412 / 423
页数：12
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