PITUITARY ADENYLATE CYCLASE-ACTIVATING PEPTIDE (PACAP), A NEW VASOACTIVE-INTESTINAL-PEPTIDE (VIP)-LIKE PEPTIDE IN THE RESPIRATORY-TRACT

被引：118
作者：
UDDMAN, R
LUTS, A
ARIMURA, A
SUNDLER, F
机构：
[1] UNIV LUND, DEPT MED CELL RES, S-22362 LUND, SWEDEN
[2] TULANE UNIV, SCH MED, HERBERT CTR, US JAPAN BIOMED RES LABS, NEW ORLEANS, LA 70112 USA
来源：
CELL AND TISSUE RESEARCH | 1991年 / 265卷 / 01期
关键词：
PITUITARY ADENYLATE CYCLASE-ACTIVATING PEPTIDE (PACAP); VASOACTIVE INTESTINAL PEPTIDE (VIP); IMMUNOCYTOCHEMISTRY; RESPIRATORY TRACT; AUTONOMIC INNERVATION; MAMMALS;
D O I：
10.1007/BF00318155
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Pituitary adenylate cyclase-activating peptide (PACAP) is a vasoactive intestinal peptide (VIP)-like peptide recently isolated from ovine hypothalami. Nerve fibers displaying PACAP immunoreactivity were found in the respiratory tract of rats, guinea pigs, ferrets, pigs, sheep and squirrel monkeys. A moderate supply of PACAP-immunoreactive fibers was seen in the nasal mucosa of guinea pigs. Few to moderate numbers of PACAP-containing fibers occurred in the tracheo-bronchial wall of rats, guinea pigs, ferrets, pigs, sheep and squirrel monkeys. The fibers were distributed beneath the epithelium, around blood vessels and seromucous glands, and among bundles of smooth muscle. In the lungs, the immunoreactive fibers were observed close to small bronchioli. A few PACAP-immunoreactive nerve cell bodies were seen in the sphenopalatine and otic ganglia of guinea pigs. Simultaneous double immunostaining of the respiratory tract of sheep and ferrets revealed that all PACAP-containing nerve fibers stored VIP. We suggest that neuronal PACAP may take part in the regulation of smooth muscle tone and glandular secretion.
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页码：197 / 201
页数：5
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