POLYISOPRENOID AMPHIPHILIC COMPOUNDS AS INHIBITORS OF SQUALENE SYNTHESIS AND OTHER MICROSOMAL-ENZYMES

被引：27

作者：

BERTOLINO, A ^{[1
]}

ALTMAN, LJ ^{[1
]}

VASAK, J ^{[1
]}

RILLING, HC ^{[1
]}

机构：

[1] UNIV UTAH,COLL MED,DEPT BIOCHEM,SALT LAKE CITY,UT 84112

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1978年 / 530卷 / 01期

关键词：

D O I：

10.1016/0005-2760(78)90122-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Analogues of farnesyl pyrophosphate containing a farnesyl moiety and a variety of amine residues replacing the pyrophosphate have been synthesized. Most of these compounds were effective inhibitors of the synthesis of squalene and presqualene pyrophosphate from farnesyl pyrophosphate. 50% inhibition was obtained at concentrations between 50 and 100 μM. These analogues also inhibited other microsomal enzymes so they apparently function as general inhibitors of microsomal enzymes. © 1978.

引用

页码：17 / 23

页数：7

共 17 条

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