Complications of Diabetes Type 2: Role of Serum hs-CRP and Serum Magnesium

Back ground: Poor glycemic control and inflammation are the main component of the pathogenesis of diabetes and its complications. Aims: To find out the correlation of serum magnesium and h-C reactive protein in relation with the complications of diabetes. Methods: About 75 subjects out of them 35 males (group 1) and 35 females patients (group 11) and 50 control with no history of any disease were selected. A questionnaire with information on variables (sex, age) and characteristics of diabetes (type of diabetes mellitus, duration of disease, mode of treatment and any complication) during consultation. Level of fasting blood glucose, serum HbA1c, hs-CRP and magnesium were estimated by standard kit methods. Results: Level of fasting blood sugar, hs-CRP, HbA1c is significantly increased in patients in contrast to controls and this shows a significant difference. However, the amount of serum magnesium was decreased significantly in diabetic patients in contrast to controls. A direct correlation was seen between hs-CRP, fasting blood sugar and Hb A1c in both male and female diabetic patients. The correlation between serum magnesium and hs-CRP was negative in patients. The correlation between HbA1c and serum magnesium was also negative in both patients. Conclusion: The correlation between hs-CRP and serum magnesium was negative in patients which may be related with poor glycemic control, which may increase the risk of complications of diabetes. However, more studies are needed on relationship of serum magnesium with serum hs-CRP to confirm their role in the prevention of complications of diabetes.