TRANSNEURONAL EFFECTS TRIGGERED BY SAPHENOUS NERVE INJURY ON ONE SIDE OF A RAT ARE RESTRICTED TO NEURONS OF THE CONTRALATERAL, HOMOLOGOUS NERVE

被引：33

作者：

KOLSTON, J ^{[1
]}

LISNEY, SJW ^{[1
]}

MULHOLLAND, MNC ^{[1
]}

PASSANT, CD ^{[1
]}

机构：

[1] UNIV WALK,SCH MED SCI,DEPT PHYSIOL,BRISTOL BS8 1TD,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1991年 / 130卷 / 02期

基金：

英国惠康基金;

关键词：

PERIPHERAL NERVE INJURY; PLASMA EXTRAVASATION; NEUROGENIC INFLAMMATION; TRANSNEURONAL SIGNALS;

D O I：

10.1016/0304-3940(91)90393-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Transection and regeneration of the saphenous nerve on one side of a rat reduces the ability of the contralateral saphenous nerve to evoke plasma extravasation following antidromic nerve stimulation. It is proposed that a transneuronal signal - that is a signal that passes from injured neurones on one side of the body to intact ones on the other via the spinal cord - is involved in triggering this response. The present experiments have shown that the influence of this transneuronal signal is restricted to neurones of homologous nerves on the two sides of an animal, i.e. it passes from saphenous nerve neurones on one side to saphenous nerve neurones on the other; its influence does not seem to extend to neurones in other nerves, for example ones in either the ipsi- or contralateral sural nerves.

引用

页码：187 / 189

页数：3

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