Endothelin receptor subtypes and their role in transmembrane signaling mechanisms

被引：118
作者：
Sokolovsky, M
机构：
[1] Laboratory of Neurobiochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv
来源：
PHARMACOLOGY & THERAPEUTICS | 1995年 / 68卷 / 03期
关键词：
endothelins; sarafotoxins; receptor subtypes; cloning; phospholipases; cAMP; cGMP;
D O I：
10.1016/0163-7258(95)02015-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The endothelins (ETs) are potent vasoactive peptides that appear to be involved in diverse biological actions, for example, contraction, neuromodulation, and neurotransmission, as well as in various pathophysiological conditions, such as renal and heart failure. The diversity of actions of ETs may be explained in terms of (1) the existence of several receptor subtypes and (2) the activation of different signal transduction pathways. This review summarizes the state of the art in this intensively studied field, with particular focus on structural aspects, receptor heterogeneity, coupling of receptors to G-proteins, and signal transduction mechanisms mediated by the activation of ET-receptors.
引用
收藏
页码：435 / 471
页数：37
相关论文
共 209 条
  • [11] GROWTH REGULATORY PROPERTIES OF ENDOTHELINS
    BATTISTINI, B
    CHAILLER, P
    DORLEANSJUSTE, P
    BRIERE, N
    SIROIS, P
    [J]. PEPTIDES, 1993, 14 (02) : 385 - 399
  • [12] INTERACTION OF ENDOTHELIN-3 WITH ENDOTHELIN-B RECEPTOR IS ESSENTIAL FOR DEVELOPMENT OF EPIDERMAL MELANOCYTES AND ENTERIC NEURONS
    BAYNASH, AG
    HOSODA, K
    GIAID, A
    RICHARDSON, JA
    EMOTO, N
    HAMMER, RE
    YANAGISAWA, M
    [J]. CELL, 1994, 79 (07) : 1277 - 1285
  • [13] DISTURBANCES IN THE CARDIOVASCULAR-SYSTEM CAUSED BY ENDOTHELIN AND SARAFOTOXIN
    BDOLAH, A
    WOLLBERG, Z
    AMBAR, I
    KLOOG, Y
    SOKOLOVSKY, M
    KOCHVA, E
    [J]. BIOCHEMICAL PHARMACOLOGY, 1989, 38 (19) : 3145 - 3146
  • [14] MUTATIONAL ANALYSIS OF HUMAN ENDOTHELIN RECEPTORS ET(A) AND ET(B) - IDENTIFICATION OF REGIONS INVOLVED IN THE SELECTIVITY FOR ENDOTHELIN-3 OR CYCLO-(D-TRP-D-ASP-PRO-D-VAL-LEU)
    BECKER, A
    HAENDLER, B
    HECHLER, U
    SCHLEUNING, WD
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1994, 221 (03): : 951 - 958
  • [15] BENBARUCH G, 1993, CANCER, V72, P1955, DOI 10.1002/1097-0142(19930915)72:6<1955::AID-CNCR2820720627>3.0.CO
  • [16] 2-3
  • [17] TISSUE-SPECIFICITY OF ENDOTHELIN BINDING-SITES
    BOLGER, GT
    LIARD, F
    KROGSRUD, R
    THIBEAULT, D
    JARAMILLO, J
    [J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1990, 16 (03) : 367 - 375
  • [18] SOLUTION CONFORMATION OF ENDOTHELIN-3 BY H-1-NMR AND DISTANCE GEOMETRY CALCULATIONS
    BORTMANN, P
    HOFLACK, J
    PELTON, JT
    SAUDEK, V
    [J]. NEUROCHEMISTRY INTERNATIONAL, 1991, 18 (04) : 491 - 496
  • [19] INVOLVEMENT OF TYROSYL RESIDUE(S) IN BINDING OF ENDOTHELIN AND SARAFOTOXIN TO THEIR RECEPTORS IN RAT-BRAIN AND HEART
    BOUSSO, D
    BDOLAH, A
    SOKOLOVSKY, M
    [J]. NEUROSCIENCE LETTERS, 1992, 140 (02) : 247 - 250
  • [20] ENDOTHELIN SARAFOTOXIN RECEPTOR HETEROGENEITY - EVIDENCE FOR DIFFERENT GLYCOSYLATION IN RECEPTORS FROM DIFFERENT TISSUES
    BOUSSOMITTLER, D
    GALRON, R
    SOKOLOVSKY, M
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 178 (03) : 921 - 926
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