INDETERMINATE 3RD-GENERATION RECOMBINANT IMMUNOBLOT ASSAY IN HEPATITIS-C VIRUS-INFECTION

被引：18

作者：

LAMORIL, J

LUNEL, F

LAURENTPUIG, P

DEFER, C

LOISEAU, P

LEFRERE, JJ

PAWLOTSKY, JM

MARCELLIN, P

BOUCHARDEAU, F

BOGARD, M

机构：

[1] HOP ST ANTOINE,INST NATL TRANSFUS SANGUINE,F-75012 PARIS,FRANCE

[2] HOP LOUIS MOURIER,BIOCHEM LAB,F-92701 COLOMBES,FRANCE

[3] HOP LA PITIE SALPETRIERE,VIROL LAB,PARIS,FRANCE

[4] KREMLIN BICETRE HOSP,VIROL LAB,PARIS,FRANCE

[5] BLOOD CTR,LILLE,FRANCE

[6] HOP ST LOUIS,CTR BLOOD,PARIS,FRANCE

[7] HOP HENRI MONDOR,VIROL LAB,F-94010 CRETEIL,FRANCE

[8] BEAUJON HOSP,DEPT HEPATOL,CLICHY,FRANCE

[9] NATL INST BLOOD TRANSFUS,PARIS,FRANCE

[10] GEN HOSP,MOLEC BIOL LAB,MEAUX,FRANCE

来源：

JOURNAL OF HEPATOLOGY | 1994年 / 21卷 / 01期

关键词：

HEPATITIS C VIRUS; POLYMERASE CHAIN REACTION; RECOMBINANT IMMUNOBLOT; SEROLOGICAL ASSAY;

D O I：

10.1016/S0168-8278(94)80150-9

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Third-generation recombinant immunoblot assay is widely used for the validation of the serological diagnosis of hepatitis C virus infection. To determine whether indeterminate recombinant immunoblot assay 3.0 patterns may be associated with viral replication and liver disease, 89 indeterminate patterns were studied (67 c22n 14 c33c, 5 c100p and 3 NS5); 35 (39%) had immunosuppression. Serum alanine aminotransferase activity was increased in 49 (55%); HCV RNA was evidenced through polymerase chain reaction in 52 (58%). The observation of indeterminate recombinant immunoblot assay 3.0 justifies investigation of liver disease and search for HCV RNA, since a large proportion of individuals with such patterns are hepatitis C virus-infected. (C) Journal of Hepatology.

引用

页码：133 / 134

页数：2

共 5 条

[1]

Martinot-Peignoux M., 1993, Journal of Hepatology, V18, pS146

[2]

PAWLOTSKY JM, 1993, HEPATOLOGY, V18, pA86, DOI 10.1016/0270-9139(93)91871-O

[3] CONFIRMATION OF HEPATITIS-C VIRUS-INFECTION BY NEW 4-ANTIGEN RECOMBINANT IMMUNOBLOT ASSAY [J].